Title : Cholecystokinin and gastrin inhibit histamine stimulated aminopyrine uptake in isolated rabbit gastric glands.

Pub. Date : 1989

PMID : 2763388






7 Functional Relationships(s)
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1 Cholecystokinin and gastrin inhibit histamine stimulated aminopyrine uptake in isolated rabbit gastric glands. Aminopyrine cholecystokinin Oryctolagus cuniculus
2 In the present study we have analyzed if cholecystokinin (CCK) or gastrin (G) can inhibit acid production in isolated rabbit gastric glands as revealed by the aminopyrine technique. Aminopyrine cholecystokinin Oryctolagus cuniculus
3 The results show that G 17 I, CCK 8 NS, CCK 8 S, ceruletide and CCK 39 significantly inhibit histamine induced aminopyrine accumulation. Aminopyrine cholecystokinin Oryctolagus cuniculus
4 The results show that G 17 I, CCK 8 NS, CCK 8 S, ceruletide and CCK 39 significantly inhibit histamine induced aminopyrine accumulation. Aminopyrine cholecystokinin Oryctolagus cuniculus
5 The results show that G 17 I, CCK 8 NS, CCK 8 S, ceruletide and CCK 39 significantly inhibit histamine induced aminopyrine accumulation. Aminopyrine cholecystokinin Oryctolagus cuniculus
6 As a group the CCK peptides were more effective than the gastrin peptides in inhibiting the aminopyrine uptake. Aminopyrine cholecystokinin Oryctolagus cuniculus
7 CCK 8 S and ceruletide, the most potent inhibitors, reduced histamine induced aminopyrine accumulation with an ED50 of 10(-9) and 10(-10) M respectively. Aminopyrine cholecystokinin Oryctolagus cuniculus