Title : Computational Analysis of Physicochemical Factors Driving CYP2D6 Ligand Interaction.

Pub. Date : 2017

PMID : 27632988






1 Functional Relationships(s)
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1 CONCLUSION: CYP2D6 binding subsite A was found to be relatively selective for small molecular weight with higher polarity compared with subsite B which tends to favor larger molecular weight and relatively hydrophobic molecules such as tamoxifen and imipramine. Imipramine cytochrome P450 family 2 subfamily D member 6 Homo sapiens