Pub. Date : 2016 Nov 1
PMID : 27614009
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 2 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 3 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 4 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 5 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 6 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 7 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 8 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 9 | The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 10 | A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated with lower DAB plasma concentrations in the Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) study participants. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 11 | The aim of this study was to examine the effect of CES1 genetic polymorphisms and gender on DABE activation using several in vitro approaches. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 12 | A personalized DABE treatment approach based on patient-specific CES1 genotypes and sex may have the potential to improve the efficacy and safety of DABE pharmacotherapy. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 13 | A personalized DABE treatment approach based on patient-specific CES1 genotypes and sex may have the potential to improve the efficacy and safety of DABE pharmacotherapy. | Dabigatran | carboxylesterase 1 | Homo sapiens |