Title : Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-γ ligands in a cyclooxygenase-2-dependent manner.

Pub. Date : 2016 Nov 1

PMID : 27612965






1 Functional Relationships(s)
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1 Next, we used a cell-based luciferase reporter to confirm the ability of HLF supernatants to activate PPARgamma, demonstrating, for the first time, that primary HLFs activated with proinflammatory IL-1beta or cigarette smoke extract produce functional PPARgamma ligands; this phenomenon is temporally regulated, COX-2- and lipocalin-type PGD synthase-dependent, and enhanced by arachidonic acid supplementation. Arachidonic Acid interleukin 1 beta Homo sapiens