Pub. Date : 2017 Mar
PMID : 27605212
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of G0S2 is coordinated by recruitment of PML/RARalpha and C/EBPepsilon to its promoter during ATRA-induced APL differentiation. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 2 | All-trans retinoic acid (ATRA) binds the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein and is an effective oncogene-targeted therapy for acute promyelocytic leukemia (APL). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 3 | All-trans retinoic acid (ATRA) binds the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion protein and is an effective oncogene-targeted therapy for acute promyelocytic leukemia (APL). | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 4 | However, the molecular basis of PML/RARalpha-mediated transcriptional control during ATRA-induced differentiation is unclear. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 5 | Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 6 | Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 7 | Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |
| 8 | Here, we performed a series of chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) experiments, demonstrating that there is an additional mode of action of PML/RARalpha, wherein PML/RARalpha does not bind DNA in the absence of ATRA but binds DNA and activates adjacent genes in the presence of ATRA. | Tretinoin | PML nuclear body scaffold | Homo sapiens |