Pub. Date : 2017 Jan
PMID : 27603596
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 2 | This paper reports that the combination of tunicamycin plus TRAIL produced a strong synergistic effect in TRAIL-sensitive human colon cancer HCT116 cells and TRAIL-resistant HT-29 cells. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 3 | This paper reports that the combination of tunicamycin plus TRAIL produced a strong synergistic effect in TRAIL-sensitive human colon cancer HCT116 cells and TRAIL-resistant HT-29 cells. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 4 | On a cellular mechanistic level, tunicamycin-enhanced TRAIL-induced apoptosis by death receptor (DR) 5 upregulation and DR4 deglycosylation. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 5 | In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 6 | In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 7 | In summary, tunicamycin effectively enhanced TRAIL-induced apoptosis might through JNK-CHOP-mediated DR5 upregulation and the inhibition of the epidermal growth factor receptor pathway. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |