Title : Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth.

Pub. Date : 2016 Sep 1

PMID : 27581364






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Physapubescin decreases the expression of HIF-2alpha and increases the expression of CCAAT/enhancer-binding protein homologus protein (CHOP), which leads to up-regulation of death receptor 5 (DR5), activation of caspase-8 and -3, cleavage of poly (ADP-Ribose) polymerase (PARP) and apoptosis. physapubescin DNA damage inducible transcript 3 Homo sapiens