Pub. Date : 2017 Feb
PMID : 27574897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Ionone was found to be oxidized via 4S-hydroxylation by CYP2B6 in human liver microsomes. | beta-ionone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Further kinetic analysis revealed that CYP2B6 exhibited the highest activity for beta-ionone 4-hydroxylation. | beta-ionone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Kinetic analysis showed that Km and Vmax for oxidation of beta-ionone by CYP1A2 and CYP2B6 was 107.9 +- 36.0 microM and 3200.3 +- 323.0 nmol/min/nmol P450 and 5.6 +- 1.2 microM and 572.8 +- 29.8 nmol/min/nmol P450, respectively. | beta-ionone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | These results suggest that beta-ionone, a norisoprenoid present in nature, is one of the effective substrates for CYP2B enzymes in human liver microsomes. | beta-ionone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |