Title : Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats.

Pub. Date : 2017 Mar

PMID : 27561292






3 Functional Relationships(s)
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1 Meanwhile, allicin decreased NF-kappaB level and upregulated expression of proteins reduced by As2O3 including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, and Kruppel-like factor 9 (KLF9). Arsenic Trioxide NFE2 like bZIP transcription factor 2 Homo sapiens
2 Meanwhile, allicin decreased NF-kappaB level and upregulated expression of proteins reduced by As2O3 including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, and Kruppel-like factor 9 (KLF9). Arsenic Trioxide NFE2 like bZIP transcription factor 2 Homo sapiens
3 In conclusion, allicin attenuated As2O3-induced hepatotoxicity by activating the Nrf2 signaling pathway involving KLF9 to inhibit oxidative stress and apoptosis. Arsenic Trioxide NFE2 like bZIP transcription factor 2 Homo sapiens