Title : Calcitonin gene-related peptide down-regulates bleomycin-induced pulmonary fibrosis.

Pub. Date : 2016 Dec

PMID : 27556497






1 Functional Relationships(s)
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1 Sensory CGRP depletion by capsaicin exacerbated bleomycin-induced pulmonary fibrosis in rats, as shown by a significant disturbed alveolar structure, marked thickening of the interalveolar septa and dense interstitial infiltration by inflammatory cells and fibroblasts, accompanied with increased expression of TGF-beta1, eIF3a, phosphorylated ERK1/2, alpha-SMA, collagen I, and collagen III. Bleomycin transforming growth factor, beta 1 Rattus norvegicus