Title : Sex differences in behavioral and PKA cascade responses to repeated cocaine administration.

Pub. Date : 2016 Oct

PMID : 27553823






5 Functional Relationships(s)
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1 Sex differences in behavioral and PKA cascade responses to repeated cocaine administration. Cocaine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 In addition, cocaine induced a sexual dimorphic pattern in the progression of neuronal adaptations on the PKA cascade signaling in region (NAc vs. CPu) and time (days of cocaine administration)-dependent manners. Cocaine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
3 In addition, cocaine induced a sexual dimorphic pattern in the progression of neuronal adaptations on the PKA cascade signaling in region (NAc vs. CPu) and time (days of cocaine administration)-dependent manners. Cocaine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
4 In general, more PKA signaling cascade changes were found in the NAc of males on day 5 and in the CPu of females with repeated cocaine injection. Cocaine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
5 Our studies suggest that repeated cocaine administration induced different patterns of behavioral and molecular responses in the PKA cascade in male and female rats. Cocaine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus