Pub. Date : 2016 Dec
PMID : 27553225
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitate inhibited IGFBP-3 secretion by THP-1 macrophages and enhanced IL-8 expression. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | Exposure of palmitate-treated THP-1 macrophages to IGFBP-3-deficient conditioned medium led to a 20-fold increase in palmitate-induced IL-8 expression by hepatocytes. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Exposure of palmitate-treated THP-1 macrophages to IGFBP-3-deficient conditioned medium led to a 20-fold increase in palmitate-induced IL-8 expression by hepatocytes. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Conversely, overexpression of IGFBP-3 suppressed JNK and NF-kappaB activation and blocked palmitate-induced IL-8 expression in hepatocytes. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | Silencing IGFBP-3 in Huh7 cells enhanced JNK and NF-kappaB activity and increased palmitate-induced IL-8 secretion. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 8 | Under lipotoxic conditions, palmitate inhibits hepatic macrophage secretion of IGFBP-3, thereby releasing the brake and enhancing palmitate-induced IL-8 synthesis and secretion.-Min, H.-K., Maruyama, H., Jang, B. K., Shimada, M., Mirshahi, F., Ren, S., Oh, Y., Puri, P., Sanyal, A. J. Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. | Palmitates | C-X-C motif chemokine ligand 8 | Homo sapiens |