Title : Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.

Pub. Date : 2016 Nov 10

PMID : 27541263






2 Functional Relationships(s)
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1 The inhibitory activity of COX-2 and 5-LOX were tested for 5a-h. Three compounds, 5c, 5d and 5f showed excellent COX-2 inhibitory activity with IC50 ranging from 0.98 to 1.23 muM compared to the reference celecoxib (1.54 muM). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The inhibitory activity of COX-2 and 5-LOX were tested for 5a-h. Three compounds, 5c, 5d and 5f showed excellent COX-2 inhibitory activity with IC50 ranging from 0.98 to 1.23 muM compared to the reference celecoxib (1.54 muM). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens