Pub. Date : 2016 Dec
PMID : 27540134
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To elucidate whether the pro-osteogenic effect of deferoxamine is mediated via Wnt signaling, we performed a Wnt profiler array of deferoxamine-treated osteoblasts. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 2 | Further analysis revealed a time- and dose-dependent induction of Wnt5a being up-regulated 2-fold after 48 h at 50 muM deferoxamine. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 3 | Pathway analysis using specific inhibitors revealed that deferoxamine utilized the phosphatidylinositol-3-kinase and nuclear factor of activated T cell pathways to induce Wnt5a expression. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 4 | Finally, we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 5 | Finally, we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 6 | The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a-/- cells. | Deferoxamine | Wnt family member 5A | Homo sapiens |
| 7 | Thus, these data demonstrate that Wnt5a is critical for the pro-osteogenic effects of iron chelation using deferoxamine. | Deferoxamine | Wnt family member 5A | Homo sapiens |