Title : Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress-Induced Damage via Induction of Nrf-2-Mediated HO-1 Expression.

Pub. Date : 2016 Sep

PMID : 27535021






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1 Preclinical Research The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2 O2 )-induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Moreover, BBH-mediated induction and activation of HO-1 were reduced by genetic silencing of Nrf2 using small interfering RNA (siRNA). alpha-hexachlorocyclohexane nuclear factor, erythroid derived 2, like 2 Mus musculus
3 In addition, the effects of BBH against H2 O2 -induced ROS accumulation and growth inhibition were abrogated in C2C12 cells transfected with Nrf2 siRNA. alpha-hexachlorocyclohexane nuclear factor, erythroid derived 2, like 2 Mus musculus
4 Therefore, the present study demonstrated that BBH could protect C2C12 cells against oxidative stress-induced injury and this effect involved activation of the Nrf2/HO-1 pathway. alpha-hexachlorocyclohexane nuclear factor, erythroid derived 2, like 2 Mus musculus