Pub. Date : 2016 Sep 6
PMID : 27528423
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner. | Clodronic Acid | interleukin 1 beta | Mus musculus |