Title : YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells.

Pub. Date : 2016 Sep 20

PMID : 27528031






2 Functional Relationships(s)
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1 Ectopic expression of c-FLIP markedly blocked YM155-induced TRAIL sensitization. YM 155 CASP8 and FADD like apoptosis regulator Homo sapiens
2 Taken together, our results suggested that YM155 sensitizes TRAIL-mediated apoptosis via down-regulation of Mcl-1 and c-FLIP expression in renal carcinoma Caki cells. YM 155 CASP8 and FADD like apoptosis regulator Homo sapiens