Title : Capsaicin-sensitive Innervation Modulates the Development of Apical Periodontitis.

Pub. Date : 2016 Oct

PMID : 27523907






3 Functional Relationships(s)
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1 The dental pulp and periradicular tissues are innervated by capsaicin-sensitive neurons known to release CGRP. Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus
2 Ablation of capsaicin-sensitive neurons was verified with confocal microscopy, capsaicin-induced eye-wipe nocifensive behavior test, and by measurement of immunoreactive CGRP levels in the dental pulp. Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus
3 In addition, the neonatal capsaicin group showed a significant depletion of susceptible neurons and CGRP in the dental pulp compared with control. Capsaicin calcitonin-related polypeptide alpha Rattus norvegicus