Pub. Date : 2016 Nov
PMID : 27523630
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Patients affected by sulfite oxidase (SO) deficiency present severe seizures early in infancy and progressive neurological damage, as well as tissue accumulation of sulfite, thiosulfate and S-sulfocysteine. | Sulfites | sulfite oxidase | Rattus norvegicus |
| 2 | Sulfite decreased reduced glutathione concentrations and the activities of glutathione reductase and glutathione S-transferase (GST) in cerebral cortex and of GST in cerebellum of SO-deficient rats. | Sulfites | sulfite oxidase | Rattus norvegicus |
| 3 | Moreover, sulfite increased the activities of complexes II and II-III in striatum and of complex II in hippocampus, but reduced the activity of complex IV in striatum of SO-deficient rats. | Sulfites | sulfite oxidase | Rattus norvegicus |
| 4 | Finally, sulfite inhibited the activities of malate and glutamate dehydrogenase in cerebral cortex of SO-deficient rats. | Sulfites | sulfite oxidase | Rattus norvegicus |