Pub. Date : 2016 Oct
PMID : 27515513
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-kappaB. | Pioglitazone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | AGEs-induced degradation of IkappaBalpha and translocation of nuclear NF-kappaB p65 is reversed by pioglitazone. | Pioglitazone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | These findings suggest that pioglitazone, a PPARgamma agonist, inhibits AGEs-induced chondrocytes apoptosis and degeneration via suppressing the activation of MAPK and NF-kappaB. | Pioglitazone | nuclear factor kappa B subunit 1 | Homo sapiens |