Title : Combination of phosphotidylinositol-3-kinase targeting with cetuximab and irradiation: A preclinical study on an orthotopic xenograft model of head and neck cancer.

Pub. Date : 2017 Jan

PMID : 27507562






1 Functional Relationships(s)
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1 The highest inhibitory effect of treatments on cell proliferation, mitogen-activated protein kinase (MAPK) and PI3K/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathways were found with the BKM120-cetuximab association. NVP-BKM120 AKT serine/threonine kinase 1 Homo sapiens