Title : Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro.

Pub. Date : 2016 Sep

PMID : 27498780






2 Functional Relationships(s)
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1 RESULTS: Glucose (1-40 mmol/L) and Ang II (10-8-10-5 mol/L) dose-dependently increased the expression of fibronectin, collagens, phospho-ERK1/2 and phospho-NF-kappaB-p65 in cardiac fibroblasts. Glucose mitogen-activated protein kinase 3 Mus musculus
2 ERK1/2 inhibitor U0126 (10 mumol/L) and NF-kappaB inhibitor JSH-23 (10 mumol/L) both markedly suppressed glucose- and angiotensin II-induced fibronectin and collagen expressions in cardiac fibroblasts. Glucose mitogen-activated protein kinase 3 Mus musculus