Pub. Date : 2016 Sep 13
PMID : 27494858
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor. | Dichloroacetic Acid | epidermal growth factor receptor | Homo sapiens |
| 2 | In the present study, we found that DCA sensitized MCF7 breast cancer cells to tamoxifen-induced cell death by decreasing epidermal growth factor receptor (EGFR) expression. | Dichloroacetic Acid | epidermal growth factor receptor | Homo sapiens |
| 3 | In the present study, we found that DCA sensitized MCF7 breast cancer cells to tamoxifen-induced cell death by decreasing epidermal growth factor receptor (EGFR) expression. | Dichloroacetic Acid | epidermal growth factor receptor | Homo sapiens |
| 4 | Furthermore, p38 mitogen-activated protein kinase played an important role in DCA/tamoxifen-induced EGFR degradation. | Dichloroacetic Acid | epidermal growth factor receptor | Homo sapiens |
| 5 | In summary, our results suggest that DCA is an attractive potential drug that sensitizes cells to tamoxifen-induced cell death and overcome tamoxifen resistance via downregulation of EGFR expression in breast cancer cells. | Dichloroacetic Acid | epidermal growth factor receptor | Homo sapiens |