Pub. Date : 2017 Feb
PMID : 27493271
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TERT Promoter Mutation Predicts Radioiodine-Refractory Character in Distant Metastatic Differentiated Thyroid Cancer. | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 2 | TERT mutation closely correlated with a poor response to radioiodine therapy (P < 0.001), and all 15 patients were classified as refractory to radioiodine therapy, with a positive predictive value of 100% at the endpoint of follow-up. | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 3 | TERT mutation was associated with older mean age at diagnosis (P < 0.001), larger mean tumor diameter (P = 0.013), and greater likelihood of both BRAF mutation coexistence (P = 0.044) and radioiodine-refractory character (P < 0.001). | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 4 | In the 36 cases whose imaging results underwent semiquantitative analysis, TERT mutation significantly correlated with non-radioiodine avidity, with a much lower mean tumor-to-background ratio (obtained from postradioiodine whole-body scanning) than in TERT wild-type cases (P < 0.001). | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 5 | In addition, patients with distant metastatic DTC with TERT mutation were more likely to lose radioiodine avidity at the initial radioiodine therapy than were those with only BRAF mutation (8/8 vs. 5/11; Fisher exact test, P = 0.018). | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 6 | In addition, patients with distant metastatic DTC with TERT mutation were more likely to lose radioiodine avidity at the initial radioiodine therapy than were those with only BRAF mutation (8/8 vs. 5/11; Fisher exact test, P = 0.018). | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 7 | CONCLUSION: TERT mutation closely associates with non-radioiodine avidity in distant metastatic DTC, and when compared with BRAF mutation, TERT mutation manifested a greater negative influence on radioiodine uptake. | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 8 | CONCLUSION: TERT mutation closely associates with non-radioiodine avidity in distant metastatic DTC, and when compared with BRAF mutation, TERT mutation manifested a greater negative influence on radioiodine uptake. | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |
| 9 | TERT mutation could also be used as an early predictor of radioiodine-refractory cases. | Iodine-131 | telomerase reverse transcriptase | Homo sapiens |