Title : Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.

Pub. Date : 2016 Oct 17

PMID : 27484786






2 Functional Relationships(s)
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1 Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization. Methyl Methanesulfonate BRCA1 DNA repair associated Homo sapiens
2 We propose a model where BRCA1 cancer variants interact with the DNA double strand break repair pathways producing DNA recombination intermediates, that maybe less repairable and decrease MMS-induced recombination and survival. Methyl Methanesulfonate BRCA1 DNA repair associated Homo sapiens