Title : Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy.

Pub. Date : 2016 Aug 2

PMID : 27480221






1 Functional Relationships(s)
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1 Our results demonstrate that imatinib binding to the kinase domain effects dynamics of proline-rich or phosphorylated peptide ligand binding sites in distal c-Src SH3 and SH2 domains. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens