Title : Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.

Pub. Date : 2016 Nov 2

PMID : 27471034






1 Functional Relationships(s)
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1 Biochemical and mass spectrometry analyses of the adducts suggested that PARPs utilise DNA termini as an alternative to 2"-hydroxyl of ADP-ribose and protein acceptor residues to catalyse PAR chain initiation either via the 2",1""-O-glycosidic ribose-ribose bond or via phosphodiester bond formation between C1" of ADP-ribose and the phosphate of a terminal deoxyribonucleotide. Deoxyribonucleotides poly(ADP-ribose) polymerase 1 Homo sapiens