Title : Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus.

Pub. Date : 2016 Sep 6

PMID : 27461790






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both morphine CPP and NO-CPP induced an upregulation of ERK, CREB phosphorylation and BDNF expression. Morphine mitogen-activated protein kinase 1 Mus musculus
2 (2) CB1R antagonist mediated blockade of ERK-CREB-BDNF signaling activation in the NAc and hippocampus may be an important mechanism underlying the attenuation of morphine CPP. Morphine mitogen-activated protein kinase 1 Mus musculus