Title : Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.

Pub. Date : 2016 Jul 27

PMID : 27460417






1 Functional Relationships(s)
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1 Whereas IDHs convert isocitrate to alpha-ketoglutarate (alpha-KG) with simultaneous reduction of NADP(+) to NADPH, these IDH mutants reduce alpha-KG to D-2-hydroxyglutarate (D-2-HG) while oxidizing NADPH. isocitric acid isocitrate dehydrogenase 1 (NADP+), soluble Mus musculus