Title : [Role of nuclear factor E2 related factor 2 signaling pathway in malignant transformation induced by sodium arsenite].

Pub. Date : 2016 May

PMID : 27459794






2 Functional Relationships(s)
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1 Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells. sodium arsenite heme oxygenase 1 Homo sapiens
2 CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation. sodium arsenite heme oxygenase 1 Homo sapiens