Pub. Date : 2016 Sep
PMID : 27449032
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a subcutaneous H22 xenograft model, evodiamine inhibited tumor growth and reduced serum tumor markers and the levels of beta-catenin and VEGFa. | evodiamine | vascular endothelial growth factor A | Mus musculus |
| 2 | Evodiamine decreased beta-catenin levels activated by LiCl, which led to reduced expression of VEGFa. | evodiamine | vascular endothelial growth factor A | Mus musculus |
| 3 | In addition, beta-catenin interacted with VEGFa and transcriptionally regulated VEGFa, an effect inhibited by evodiamine in HCCs. | evodiamine | vascular endothelial growth factor A | Mus musculus |
| 4 | In addition, beta-catenin interacted with VEGFa and transcriptionally regulated VEGFa, an effect inhibited by evodiamine in HCCs. | evodiamine | vascular endothelial growth factor A | Mus musculus |
| 5 | Moreover, in an SMMC-7721 xenograft model, evodiamine suppressed tumor growth, various biomarkers of angiogenesis, and the levels of beta-catenin and VEGFa. | evodiamine | vascular endothelial growth factor A | Mus musculus |
| 6 | Evodiamine has anti-tumor effects on HCCs through inhibiting beta-catenin, which interacts with and reduces VEGFa expression, thus inhibiting angiogenesis. | evodiamine | vascular endothelial growth factor A | Mus musculus |