Title : Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione.

Pub. Date : 2016 Aug

PMID : 27441453






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1 Using menadione as the redox-cycling chemical, we discovered that this enzymatic reaction blocks metabolic activation of parathion in rat and human liver microsomes and in recombinant CYPs important to parathion metabolism, including CYP1A2, CYP2B6, and CYP3A4. Parathion cytochrome P450 family 2 subfamily B member 6 Homo sapiens