Title : The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.

Pub. Date : 2016 Sep

PMID : 27424123






1 Functional Relationships(s)
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1 Inhibition of ERK1/2 by PD98059, JNK by SP600125 or GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by kahweol. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens