Title : Oxidation Protection in Metal-Binding Peptide Motif and Its Application to Antibody for Site-Selective Conjugation.

Pub. Date : 2016

PMID : 27420328






3 Functional Relationships(s)
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1 The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding. Metals mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 The tandem repeats of the Cysteine-Glycine-Histidine (CGH) metal ion binding motif exhibited concerted binding to Co(II) ions, suggesting that conformational transition of peptide was triggered by the sequential metal ion binding. Metals mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)>Ni(II)>Co(II). Metals mitochondrially encoded cytochrome c oxidase II Homo sapiens