Title : The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer.

Pub. Date : 2016 Aug 2

PMID : 27409664






1 Functional Relationships(s)
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1 Furthermore, downregulation of CTBP1 by miR-644a upregulates wild type- or mutant-p53 which acts as a "molecular switch" between G1-arrest and apoptosis by inducing cyclin-dependent kinase inhibitor 1 (p21, CDKN1A, CIP1) or pro-apoptotic phorbol-12-myristate-13-acetate-induced protein 1 (Noxa, PMAIP1), respectively. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens