Title : N-acetylcysteine pretreatment attenuates paraquat-induced lung leak in rats.

Pub. Date : 1995 Nov

PMID : 27405831






3 Functional Relationships(s)
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1 We found that administering a single intravenous dose (60 mg/kg) of paraquat rapidly (2 h) increased lung leak, lung lavage cytokine-induced neutrophil chemoattractant (CINC) levels, and lung myeloperoxidase (MPO) activity in rats. Paraquat myeloperoxidase Rattus norvegicus
2 We found that administering a single intravenous dose (60 mg/kg) of paraquat rapidly (2 h) increased lung leak, lung lavage cytokine-induced neutrophil chemoattractant (CINC) levels, and lung myeloperoxidase (MPO) activity in rats. Paraquat myeloperoxidase Rattus norvegicus
3 In contrast, NAC pretreated rats given paraquat had the same lung lavage CINC levels and lung tissue MPO activity as saline-pretreated rats given paraquat. Paraquat myeloperoxidase Rattus norvegicus