Pub. Date : 2017
PMID : 27401064
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on multiaspect roles of Rho kinase inhibitor Fasudil on neuroprotection, neurorepair and immunomodulation, we observed therapeutic potential of Fasudil and explored possible mechanisms in amyloid precursor protein/ presenilin-1 transgenic (APP/PS1 Tg) mice, an animal model of Alzheimer"s disease. | fasudil | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | RESULTS: Fasudil treatment ameliorated learning and memory deficits, accompanied by reduced Abeta deposition, Tau protein phosphorylation, and BACE expression, as well as increased PSD-95 expression in hippocampus. | fasudil | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | The study provides preclinical evidence that Fasudil treatment ameliorated memory deficits in APP/PS1 Tg mice, accompanied by the reduction of Abeta deposition and Tau protein phosphorylation, the decrease of BACE and the increase of PSD-95, as well as inhibition of TLRs-NF-kappaB-MyD88 inflammatory cytokine axis. | fasudil | amyloid beta (A4) precursor protein | Mus musculus |