Pub. Date : 2016 Jul 19
PMID : 27391435
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report that Parp1-deficient mice expressing increased Aag (AagTg/Parp1-/-) develop sex-dependent kidney failure upon exposure to the alkylating agent, methyl methanesulfonate (MMS), and suffer increased whole-animal lethality compared to AagTg and wild-type mice. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | Here we report that Parp1-deficient mice expressing increased Aag (AagTg/Parp1-/-) develop sex-dependent kidney failure upon exposure to the alkylating agent, methyl methanesulfonate (MMS), and suffer increased whole-animal lethality compared to AagTg and wild-type mice. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | Here we report that Parp1-deficient mice expressing increased Aag (AagTg/Parp1-/-) develop sex-dependent kidney failure upon exposure to the alkylating agent, methyl methanesulfonate (MMS), and suffer increased whole-animal lethality compared to AagTg and wild-type mice. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 4 | Pharmacological Parp inhibition in AagTg mice also resulted in sensitivity to MMS-induced nephrotoxicity. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 5 | These findings provide in vivo evidence that Parp1 modulates Aag-dependent MMS-induced nephrotoxicity in a sex-dependent manner and highlight the critical roles that Aag-initiated BER and Parp1 may play in determining the side-effects of chemotherapeutic alkylating agents. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |