Title : Enantioselective inhibition of Cytochrome P450-mediated drug metabolism by a novel antithrombotic agent, S002-333: Major effect on CYP2B6.

Pub. Date : 2016 Aug 25

PMID : 27387538






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Of the CYP enzymes tested, CYP2B6-catalyzed bupropion 6-hydroxylation was inhibited by S002-333 (IC50 ~ 9.25 +- 2.46 muM) in a stereoselective manner with (S)-isomer showing potent inhibition (IC50 ~ 5.28 +- 1.25 muM) in contrast to (R)-isomer which showed negligible inhibition on CYP2B6 activity (IC50 > 50 muM). Bupropion cytochrome P450 family 4 subfamily F member 3 Homo sapiens