Title : Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells.

Pub. Date : 2017 Mar

PMID : 27369375






2 Functional Relationships(s)
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1 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). usnic acid NAD(P)H quinone dehydrogenase 1 Homo sapiens