Title : Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.

Pub. Date : 2016 Aug

PMID : 27368132






1 Functional Relationships(s)
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1 Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-gamma-linolenic acid (DGLA, an omega-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream omega-6, arachidonic acid). Arachidonic Acid mitochondrially encoded cytochrome c oxidase II Homo sapiens