Pub. Date : 2016 Aug 26
PMID : 27365393
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. | Serine | leukotriene C4 synthase | Homo sapiens |
| 2 | Comparative molecular dynamics indicated that Ser(36) upon phosphorylation will pull the first luminal loop of LTC4S toward the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104) in the adjacent subunit. | Serine | leukotriene C4 synthase | Homo sapiens |
| 3 | Thus, our mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery. | Serine | leukotriene C4 synthase | Homo sapiens |