Title : Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis.

Pub. Date : 2016 Jul 19

PMID : 27364007






2 Functional Relationships(s)
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1 Thus, 5-IP7 appears to act through Syt1 binding to interfere with the fusogenic activity of Ca(2+) These findings reveal a role of 5-IP7 as a potent inhibitor of Syt1 in controlling the synaptic exocytotic pathway and expand our understanding of the signaling mechanisms of inositol pyrophosphates. inositol pyrophosphates synaptotagmin 1 Rattus norvegicus
2 Thus, 5-IP7 appears to act through Syt1 binding to interfere with the fusogenic activity of Ca(2+) These findings reveal a role of 5-IP7 as a potent inhibitor of Syt1 in controlling the synaptic exocytotic pathway and expand our understanding of the signaling mechanisms of inositol pyrophosphates. inositol pyrophosphates synaptotagmin 1 Rattus norvegicus