Title : Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1.

Pub. Date : 2016 Jul 1

PMID : 27363897






3 Functional Relationships(s)
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1 In addition, MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation are dependent on Fyn activation. Tyrosine C-C motif chemokine ligand 2 Homo sapiens
2 Upstream to Fyn, MCP1 stimulated C-C chemokine receptor type 2 (CCR2) and Gi/o and inhibition of either one of these molecules using their specific antagonists or inhibitors attenuated MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation. Tyrosine C-C motif chemokine ligand 2 Homo sapiens
3 Upstream to Fyn, MCP1 stimulated C-C chemokine receptor type 2 (CCR2) and Gi/o and inhibition of either one of these molecules using their specific antagonists or inhibitors attenuated MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation. Tyrosine C-C motif chemokine ligand 2 Homo sapiens