Title : KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress.

Pub. Date : 2016 Oct

PMID : 27363720






2 Functional Relationships(s)
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1 Our findings suggest that, during aging-related oxidative stress, SOD upregulation and downregulation of catalase and GPX1, which occur upon altering the sphingolipid composition or acyl chain length, generate H2 O2 and thereby upregulate KCa 3.1 expression and function via a H2 O2 /Fyn-mediated pathway. Hydrogen Peroxide catalase Mus musculus
2 Our findings suggest that, during aging-related oxidative stress, SOD upregulation and downregulation of catalase and GPX1, which occur upon altering the sphingolipid composition or acyl chain length, generate H2 O2 and thereby upregulate KCa 3.1 expression and function via a H2 O2 /Fyn-mediated pathway. Hydrogen Peroxide catalase Mus musculus