Title : Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.

Pub. Date : 2016 Aug 15

PMID : 27353888






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Notably, compounds 34 and 38 appeared as most active multifunctional agents in the entire series and exhibited excellent inhibition against AChE (IC50=0.048muM: 34; 0.036muM: 38), Abeta aggregation (max% inhibition 82.2%, IC50=9.2muM: 34; max% inhibition 80.9%, IC50=10.11muM: 38) and displayed significant antioxidant potential in ORAC-FL assay. fluorescein (3',6'-dihydroxyspiro(isobenzofuran-1(3H), 9'(9H)-xanthen)-3-one) acetylcholinesterase (Cartwright blood group) Homo sapiens