Title : Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.

Pub. Date : 2016 Aug

PMID : 27348090






1 Functional Relationships(s)
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1 A 2.4-A-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate. oxo homeobox C13 Homo sapiens