Title : Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.

Pub. Date : 2017 Jul

PMID : 27324791






4 Functional Relationships(s)
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1 PQ selectively induced metabolomic alterations and adenosine monophosphate-activated protein kinase (AMPK) activation in the midbrain and striatum of mice chronically treated with PQ. Paraquat protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 PQ selectively induced metabolomic alterations and adenosine monophosphate-activated protein kinase (AMPK) activation in the midbrain and striatum of mice chronically treated with PQ. Paraquat protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 Inhibition of AMPK signaling led to metabolic dysfunction and an enhanced sensitivity of dopaminergic cells to PQ. Paraquat protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
4 In addition, activation of AMPK by PQ was prevented by inhibition of the inducible nitric oxide syntase (iNOS) with 1400W, but PQ had no effect on iNOS levels. Paraquat protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens