Pub. Date : 2016 Sep
PMID : 27323294
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450 (P450) 3A (CYP3A) is an enzyme responsible for the metabolism of therapeutic drugs such as midazolam, nifedipine, testosterone and triazolam. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | It involves the employment of a CYP3A substrate cocktail (including midazolam, testosterone and nifedipine). | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The concentration of each CYP3A probe substrate in vitro was optimized (0.1 mum for midazolam, 2 mum for testosterone and 2 mum for nifedipine) to minimize mutual drug interactions among probe substrates. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |