Pub. Date : 2017
PMID : 27306567
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic Acid Signaling in P19 Stem Cell Differentiation. | Tretinoin | interleukin 23, alpha subunit p19 | Mus musculus |
| 2 | P19 ES cells can differentiate to endodermal-like, mesodermal-like, and neuronal-like phenotypes in response to specific morphogens including RA and dimethyl sulfoxide (DMSO). | Tretinoin | interleukin 23, alpha subunit p19 | Mus musculus |
| 3 | At low concentrations, RA directs P19 ES cells to differentiate into cells displaying an endodermal phenotype, whereas at higher concentrations it induces differentiation to neuroectoderm. | Tretinoin | interleukin 23, alpha subunit p19 | Mus musculus |
| 4 | In addition to summarizing the reports on gene/protein targets of RA in stem cells, the signaling pathways driven by some of the specific class of proteins in the presence or absence of RA in P19 ES cell differentiation, especially to an endodermal phenotype, are the focus of this review. | Tretinoin | interleukin 23, alpha subunit p19 | Mus musculus |